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Gastrointestinal/Nutrition (GIN): Week 3

Week 3

November 6-10

Week 3 - Pathology TBL

Inflammatory Bowel Disease, Malabsorption and Diarrhea

Pre-Class Assignments:


Rx Bricks:

Foundational Objectives:

  1. Compare the gross pathology and histopathology of ulcerative colitis and Crohn disease.
  2. Correlate clinical and pathologic features of ulcerative colitis and Crohn disease.
  3. Explain potential complications of Crohn disease and ulcerative colitis.
  4. List four major categories of diarrhea based on pathogenesis.
  5. Analyze the four phases of nutrient absorption and how they relate to different etiologies of malabsorption syndromes.

Integrative Objectives:

  1. Determine how newer therapies intervene in the pathogenetic sequence of IBD.
  2. Interpret the pathogenetic factors of IBD.
  3. Summarize laboratory tests useful in the diagnosis of celiac disease.
  4. Explain laboratory tests that help distinguish malabsorption syndromes due to pancreatic insufficiency and intestinal mucosal abnormalities.
  5. Outline basic statistical principles of laboratory tests: sensitivity, specificity, positive predictive value, and negative predictive value.  
  6. Correlate the pathogenesis and clinical features of celiac disease with characteristic histopathologic changes in the small intestine and laboratory diagnostics.
  7. Outline the most important short- and long- term and complications of celiac disease.  
  8. Categorize malabsorption syndromes based on etiological factors.