Gastrointestinal/Nutrition (GIN): Week 2

Pre-Class Assignments

Chapters:

Rx Bricks:

Foundational Objectives:

1. Describe the pathogenesis and etiology of esophageal ulcers (infectious, chemical, etc). 
2. Discuss the pathogenesis of gastroesophageal reflux disease (GERD).
3. Explain the pathogenesis of Barrett esophagus and its relationship to GERD. 
4. Outline the histologic sequence and molecular events responsible for progression of glandular metaplasia to esophageal adenocarcinoma in Barrett esophagus. 
5. Correlate the unique biology of Helicobacter pylori and its role in the pathogenesis of peptic ulcers. 
6. Summarize advantages and disadvantages of tests available for diagnosis of H. pylori infections. 

Integrative Objectives:

1. Contrast histopathology, etiology, pathogenesis, and clinical features of chronic gastritis due to H. pylori and autoimmune gastritis.  
2. Classify anemias based on mean cell volume (MCV) of red blood cells. 
3. Explain the role of cellular and humoral immunity in the development of autoimmune gastritis. 
4. Depict the biochemical events responsible for megaloblastic anemias. 
5. Predict neoplastic complications of autoimmune gastritis based on its pathogenesis.