Gastrointestinal/Nutrition (GIN): Path TBL

Esophagus and Stomach

Pre-Class Assignments

Chapters:

Rx Bricks:

Objectives:

1. Describe the pathogenesis, histology and etiology of esophageal disorders such as ulcers (infectious, chemical, etc), GERD, Barret esophagus and esophageal carcinomas.

2. Contrast histopathology, etiology, pathogenesis, and clinical features of chronic gastritis due to H. pylori and autoimmune gastritis.

3. Summarize advantages and disadvantages of tests available for diagnosis of H. pylori infections

4. Explain the role of cellular and humoral immunity in the development of autoimmune gastritis.

5. Predict neoplastic and non-neoplastic complications of autoimmune gastritis based on its pathogenesis

Liver Pathology 

Pre-Class Assignments

Chapters:

Rx Bricks:

Objectives:

1. Explain the gross and microscopic features of cirrhosis and correlate them with clinical manifestations and complications. 
2. Contrast the pathogenesis, histopathology, and clinical presentations of hepatotropic viruses (A, B, C, D, E), with emphasis on chronic hepatitis C.
3. Distinguish autoimmune hepatitides, cholestatic syndromes, and inherited metabolic liver diseases based on their pathogenesis, histopathology, and clinical features.
4. Discuss diagnostic strategies for cirrhosis, viral hepatitis, autoimmune liver diseases, cholestatic syndromes, and metabolic liver disorders.
5. Illustrate the natural history, histopathologic progression, and complications of chronic hepatitis C, including implications for treatment.
6. Identify molecular targets and mechanisms of antiviral medications used in the treatment of chronic hepatitis C.

Inflammatory bowel disease, Infections enterocolitides

Pre-Class Assignments

Chapters:

Rx Bricks:

Objectives:

1. Compare the gross pathology and histopathology of ulcerative colitis and Crohn disease and correlate their clinical and pathologic features, including potential complications of both diseases.

2. Interpret the pathogenetic factors of IBD and how newer therapies intervene in its pathogenetic sequence.

3. List four major categories of diarrhea based on pathogenesis.

4. Differentiate agents of infectious enterocolitides based on etiology, pathogenesis and histopathology.

5. Discuss diagnostic methods for infectious enterocolitides and identify principles of antibiotic therapy based on mechanisms of action.

Liver Pathology

Pre-Class Assignments

Chapters:

Rx Bricks:

Foundational Objectives:

1. Discuss the gross appearance and histopathology of cirrhosis. 
2. Contrast the different hepatotropic viruses (A, B, C, D, E) regarding their pathogenesis and clinical presentation.  
3. Differentiate autoimmune hepatitides, cholestatic syndromes and metabolic disorders regarding pathogenesis, histopathology and clinical presentation. 
4. Correlate the histopathology metabolic alterations of cirrhosis with its clinical presentation and complications.   
5. Discuss the different diagnostic alternatives for cirrhosis, viral hepatitides, autoimmune hepatitides, cholestatic syndromes and metabolic diseases affecting the liver.

Integrative Objectives:

1. Illustrate the natural history of chronic hepatitis C infection.
2. Identify the main clinical features and laboratory findings of chronic hepatitis C infection.
3.  Explain the histopathologic progression of hepatitis C infection and its implications for treatment.
4. Identify the main complications arising from chronic hepatitis C infection and their possible pathogenetic mechanisms.
5. Analyze molecular targets of antiviral medications used for chronic hepatitis C infection.

Inflammatory Bowel Disease, Malabsorption and Diarrhea

Pre-Class Assignments:

Chapters:

Rx Bricks:

Objectives:

1. Analyze the four phases of nutrient absorption and how they relate to different etiologies and categories of malabsorption syndromes.
2. Correlate the pathogenesis and clinical features of celiac disease, including its complications, with characteristic histopathologic changes in the small intestine and laboratory diagnostics.
3. Identify different variants of colonic adenocarcinomas and recognize the principles of grading and staging of colorectal cancer.
4. Recognize the main categories of neoplastic polyps and their malignant potential.
5. Outline the genetic mutations and assess the functional roles of the mutated genes in oncogenesis (familial and sporadic), including the main polyposis syndromes.

Pancreatic Pathology 

Pre-Class Assignments

Chapters:

Rx Bricks:

Objectives:

1. Explain the pathogenesis, etiology, and complications of acute and chronic pancreatitis, including hereditary forms and their genetic basis.
2. Differentiate diagnostic features of acute vs. chronic pancreatitis using clinical and pathological criteria.
3. Describe the molecular and clinical features of pancreatic neoplasms, including adenocarcinoma, cystic neoplasms, and neuroendocrine tumors.
4. Apply principles of clinical laboratory testing, including sensitivity, specificity, predictive values, and ROC curves, to pancreatic disease diagnosis.  
5. Identify and compare types of epidemiological study designs, including descriptive and analytical observational studies.