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Molecules, Cells, and Tissues: Week 6 - Week 7

Week 6 - Week 7

 

Rx Bricks - Required

Rx Bricks - Supplemental Readings

  • Sub: Biomedical Importance; Membranes are Complex Structures Composed of Lipids, Proteins, & Carbohydrate-containing Molecules; Membrane Selectivity Allows Adjustments of Cell Composition & Function through Transport of Glucose Involves Several Mechanisms; Gap Junctions Allow Direct Flow of Molecules from One Cell to Another; 
  • Sub: Cells Transport Certain Macromolecules Across the Plasma Membrane by Endocytosis & Exocytosis through Extracellular Vesicles (Exosomes) Represent a Novel, & Previously Underappreciated Mechanism of Cell-Cell Communication
  • Sub: Many Proteins Are Targeted by Signal Sequences to Their Correct Destinations; The Cytosolic Protein Sorting Branch Directs Proteins to Subcellular Organelles; Proteins Follow Several Routes to be Inserted into or Attached to the Membranes of the Endoplasmic Reticulum through Transport Vesicles Are Key Players in Intracellular Protein Traffic
  • Sub: The Cytoskeleton Performs Multiple Cellular Functions
  • Sub: Transport Across Epithelia; Characteristic Features of Epithelial Cells; Specialization of the Apical Cell Surface; Types of Epithelia”
  • Sub: Pathophysiology; Natural History and Prognosis; Complications.

TBL 7: Metabolism

Learning Objectives:

1. EXPLAIN the metabolic pathways and hormonal regulation of glucose homeostasis during different physiological states (fed, fasting, starvation, and exercise) in the liver, skeletal muscle, and adipocytes.

2. IDENTIFY the key substrates and their roles in gluconeogenesis, especially during fasting, and explain how these substrates are utilized for glucose production.

3. ANALYZE the pathophysiology of diabetes mellitus, including the mechanisms behind hyperglycemia in type 1 and type 2 diabetes.

4. EVALUATE the impact of dietary components (such as high fructose corn syrup) on metabolic pathways and their consequences for conditions like fatty liver disease and insulin resistance.

Rx Bricks:

Specific TBL Reading Material: