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School of Nursing - BSN

Systematic Reviews - Levels of Evidence: not all evidence is created equal (from the Cochrane Collaboration)

1.  Strength of the evidence:  The quality of the evidence is determined by the methods used to minimize bias within a study design...

2.  Relevance of the evidence:  How appropriate is the outcome measure for the healthcare problem, and how useful is it in measuring the benefits?  

3.  Size of the effect:  How high is the likelihood that the effect of the treatment will achieve clinically relevant benefits (or harms)?

4.  Lower levels of evidence are provided by:

  • Non-randomized studies... where a control group has run concurrently...
  • Non-randomized studies... where intervention effects are compared...
  • Single case studies

5.  Confidence interval (CI):

Even studies that are perfectly designed and carried out may show variable results because of the play of chance.  CI covers the likely range of the true effect...

* This information has been extracted from the Cochrane Collaboration website.  To see the complete document:  

Levels of Evidence Pyramid

John Hopkins Nursing Evidence-Based Practice

Tools available for your use (linked within the book)

Rating System

Hierarchy of Evidence for Intervention/Treatment Questions

(In descending order)

 Level I

Evidence from a systematic review of meta-analysis of all relevant RCTs
Level II Evidence obtained from well-designed RCTs
Level III Evidence obtained from well-designed controlled trials without randomization
Level IV
Evidence from well-designed case-control and cohort studies
Level V
Evidence from systematic reviews of descriptive and qualitative studies
Level VI
Evidence from single descriptive or qualitative studies
Level VII Evidence from the opinion of authorities and/or reports of expert communities

*Table taken from Evidence-Based Practice in Nursing and Healthcare:  A Guide to Best Practice, 2011, page 12. 

Print Volume, 4th floor

Call Number, WY 100.7 M527e 211

The Center for Evidence-Based Medicine: Levels of Evidence

Hierarchies of evidence from the CEBM.  The three documents linked here should be used together to provide a better understanding.